Boltz-2

GitHub Repository
  • Predicts the 3D structure of proteins, rna, dna and small molecules
  • Handles modified residues, covalent ligands and glycans, as well as condition the generation on pocket residues
  • Matches or outperforms AlphaFold3
  • Predict binding affinity given a binder chain

Est. run time: 20m


Version Boltz 2.2.0


Add Protein, RNA/DNA, and Ligand structures to your complex below.

Examples

Number of structure predictions to return

Predict Affinity

Number of rounds of refinement during structure prediction (higher values may improve accuracy but take longer)

Lower step scale means more diversity (recommended between 1 and 2)

This will submit x jobs with numSamples designs each to run in parallel

Template CIFs

Upload template CIF files to guide the structure prediction. These will be used as templates for the prediction.

Controls the distance (in Angstroms) that the prediction can deviate from the template

Please add one or more structures to your complex





Structure Prediction