Protein Design

Design a new protein using RFdiffusion and score it for various properties
Design a binder to a target, scaffold an existing motif, or diversify your protein to generate variants
Score for properties like thermostability, solubilty, and binding affinity

If you're designing antibodies, try our IgDesign tool for better results.

Job Name

1. Select what task you'd like to perform with RFdiffusion.

Binder Design - design a de novo protein binder for your target
Binder Redesign - redesign parts of an existing chain in a binder/target complex
Motif Scaffolding - generate new structures to scaffold an existing motif on your protein
Partial Diffusion - diversify parts or all of your protein to optimize for different metrics, such as solubility and thermostability and others.

Task

2. Upload a protein to use with RFdiffusion.

View Optional Settings

Select how many sequences to generate using ProteinMPNN for each designed backbone , and how many of those sequences to predict using Alphafold (filtered by MPNN confidence).

# of Sequences

Specify any amino acids you'd like to omit from being sampled.

Omit Amino Acids

Select your # recycles and model type for Alphafold.

Number of Recycles

Use multimer model (alphafold_multimer_v3)

Select any additional residues you'd like to be designed using ProteinMPNN by specifying {chain}{residue} (ex. A10 B15).

Additional Designed Residues

# of Filtered Sequences

No pdb file uploaded

Submit 1 job